Activon Medical Grade Manuka Honey 25g (Pack of 3)

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Hydrogel is commonly used as a wound dressing. It is composed of polymers suspended in water and is thought to provide hydration to a wound and promote healing. El-Kased et al (2017) 53 reported that an Egyptian honey (75%) chitosan hydrogel formula had superior antimicrobial activity against P. aeruginosa, S. aureus, K. pneumonia and Streptococcus pyogenes in a disc diffusion assay in comparison to pure honey. For example, the mean zone of inhibition for the honey 75% chitosan hydrogel formula against S. aureus was 20.2 ± 0.4 vs 15.1 ± 0.9 for honey. This formula was also superior to pure honey in the healing of 10 mm burn wounds induced in mice using a heated metallic rod. The wounds were treated with either the honey 75% chitosan hydrogel formula or honey for 9 days. By day 9, the honey chitosan treated wounds had a mean diameter of 3.8 ± 0.2 mm versus 5.3 ± 0.8 mm in the honey only treated group. Furthermore, an alginate-based honey hydrogel containing thymol-based honey from Damavand, Iran was reported to have superior wound healing ability in rats with infected burn wounds than honey alone. 54 Wound healing was faster in the alginate-based honey hydrogel treated group in comparison to the honey only group. In another study, a paste composed of carboxymethyl cellulose hydrogel (50%), water (30%) and chestnut honey (20%) had superior antimicrobial activity against S. aureus and E.coli in a disc diffusion assay than a paste composed of carboxymethyl cellulose hydrogel (50%) and water only. 55 Furthermore, the paste containing 20% chestnut honey had superior wound healing ability in comparison to the paste without honey in the treatment of wounds inflicted in the dorsal skin of mice. Tavaloki and Tang (2017) 56 designed a wound dressing consisting of a high concentration of honey, polyvinyl alcohol hybrid hydrogel and borax as a crosslinking agent. High concentrations of honey are important for wound healing but can negatively affect the physicochemical properties of hybrid hydrogels. The use of borax apparently overcomes this problem and permits the incorporation of high concentrations of honey without negative effects. Although the honey is not absorbed into the blood stream, we advise monitoring the levels of patients with diabetes.

Supplementation of honey with vitamin C reduced the MIC of all honey types tested against planktonic P. aeruginosa. Supplementation of honeydew honey with vitamin C increased the MIC against planktonic S. aureus. Kwakman et al (2011) 52 investigated the antimicrobial effects of supplementing Revamil honey with the antimicrobial peptides LL-37 and the synthetic peptide bacterial peptide 2 (BP2). They reported that the antimicrobial activity of LL-37 was inhibited in the presence of honey, but this was not the case for BP2. Using a liquid bactericidal assay, it was shown that Revamil honey supplemented with 75µM BP2 had more rapid antibacterial activity against MRSA and extended spectrum β lactamase (ESBL) E. coli and had a broader spectrum of antibacterial activity than Revamil alone. The authors considered supplementing the honey with hydrogen peroxide or MGO but were concerned that high levels of these components may not be biocompatible. Surgihoney™RO ® and Comvita ®Medihoney ® Antibacterial Wound Gel™ increased the sensitivity of S. aureus to tetracycline and ampicillin. Xtrasorb® – the best in the list of wound care dressings. Product review.– the best wound absorbent dressing. It is recommended to be used after applying Medihoney or Activon, or other medical grade honey you have. This cover dressing will ensure the safety of the wound, while absorbing and retaining the fluid, even under exterior pressure.Honey and ginger combination induced higher mean zones of inhibition than honey or ginger alone or standard antibiotic discs (methicillin, penicillin, amoxicillin). Synergistic antimicrobial activity against MRSA for manuka honey and tetracycline, imipenem and mupirocin combinations and additive activity against P. aeruginosa for manuka honey and tetracycline, rifampicin and colistin combinations. For each honey type there was > 90% decrease in the MIC when 3% (v/v) royal jelly was added; a 66.6% decrease when 2% (v/v) royal jelly was added and a 50% decrease in MIC when 1% (v/v) royal jelly was added. Here are other details on Activon Manuka Honey from its producer Advances Medical. What is Eclypse?

The first thing that should be done is to remove the cause of the inflammation, which is to kill the infecting bacteria and remove any pus or dead tissue, that provide a medium for their growth. How does honey heal? Activon works through the natural properties of the manuka honey, which has the following properties and effects: All honeys are good for healing skin conditions. They work through the 4 factors from the list above. If you need recurring bulk supply for a business, restaurant, or retail store, we can set you up with a business account. This provides benefits like discounted pricing, dedicated account management, and tailored delivery options. L-Mesitran demonstrated antifungal activity against C. albicans (MIC 25%–50%), whereas 40% Mexican yucatan honey did not.

Activon Manuka Honey® Tube

Comvita ®Medihoney ® Antibacterial Wound Gel™, Comvita ® Manuka Medihoney ® and Surgihoney™RO ® enhanced the sensitivity of P. aeruginosa to tetracycline. Several researchers have explored the effects of combining honey with antibiotics on antimicrobial activity in vitro. One of the first papers reporting a synergistic effect of honey and antibiotics was published in 1998. The researchers used a broth dilution assay to demonstrate a synergistic effect of an Indian honey (obtained from Phondaghat Pharmacy) and the antibiotics amikacin, ceftazidime and gentamicin against multidrug-resistant clinical isolates of P. aeruginosa. 20 The honey and antibiotics were reportedly tested at a ratio of 1:1. Experiments were also conducted with Klebsiella species, but no synergy was observed with this micro-organism. Later in 2005, another study reported synergy using broth dilution method between an Omani honey (50%) and the antibiotic gentamicin (4µg/mL) against Staphylococcus aureus. 21 Additionally, a study conducted in Egypt reported enhanced effects of antibiotics against clinical isolates of P. aeruginosa, Enterobacter species and Staphylococci in a disc diffusion assay when citrus bee honey (100%) was added to the antibiotic discs (Oxoid). 22 Clindamycin or oxacillin manuka honey combinations demonstrated synergistic antimicrobial activity against most strains (planktonic and biofilm formation) but not all.

Zone of inhibition induced by the herbal gel formulation was greater than honey alone (35.1 mm vs 13.1 mm respectively). Wound Healing Properties: De-brides and de-sloughs, eliminates odors & maintains a moist wound environment. Medical grade honey is manuka honey that has been was sterilized from all impurities and microorganisms (spores). Rich in Manuka Honey: Known for its antibacterial and healing properties, this ensures wounds recover faster.

Rifampicin and manuka honey considered to be most effective as demonstrated synergistic antimicrobial activity against all tested strains including planktonic bacteria and S. aureus biofilm formation.